To better specify the method through which teacher leaders are exerting in the entrepreneurial education in Chinese higher education institutions, the gender differences in entrepreneurial intentions is investigated as necessary to allocate the limited resources and thus meet students’ needs. Based on the classic Theory of Personal Behaviour, this work analyzed the extent and determinants of gender differentials in the entrepreneurial intentions of Chinese college students with Blinder-Oaxaca decomposition method. The data came from a field survey of 620 Chinese college students. The result suggested that, instead of discrimination and stereotypes, gender difference in entrepreneurial intentions was primarily due to the different endowments. Hence, the leaders who take a more hierarchical position of facilitator, decision-maker or mediator in the entrepreneurial education, teachers should pay more attention to the educational approaches in accordance with the different aptitudes between female and male students. Different curriculum that target those gender qualifications would be required to balance the gender difference in entrepreneurial intentions of college students.